Peer-Reviewed Publications

The reliability of xTAG RVP and its utility in the clinical setting have been described in many peer-reviewed publications by independent and Luminex-sponsored investigators. This library contains links to recent key studies, either as freely available online versions (if available) or as PubMed or other citations.
 

General information on xTAG RVP

Development of a respiratory virus panel test for detection of twenty human respiratory viruses by use of multiplex PCR and a fluid microbead-based assay.
Mahony et al., JCM 2007 Sep;45(9):2965-70. Epub 2007 Jun 27.

• Key paper describing the design and validation of the xTAG RVP assay. Free fulltext version

Respiratory Viral Diagnostics: The Pathogens, the Challenges and the Solutions. Introducing the xTAG™ Respiratory Viral Panel.
JCV 2007, Suppl 1. Comprehensive supplement describing diagnosis of respiratory infections, strengths and weaknesses of available tests, and the role of xTAG RVP. Supplement available as pay-per-view or through institutional subscriptions

Includes the following articles:

Background on respiratory infections

• Carman, W. Introduction.
• Templeton, KE. Why diagnose respiratory viral infection?
• Carman, WF and Mahony, JB. The pathogens.

Other tests for respiratory viruses

• Ginocchio, CC. Detection of respiratory viruses using non-molecular based methods.
• Fox, JD. Nucleic acid amplification tests for detection of respiratory viruses.

xTAG RVP

• Merante, F et al. Principles of the xTAG™ respiratory viral panel assay (RVP Assay)
• Mahony, JB. The clinical need for the RVP test.
• Krunic, N et al. xTAG RVP assay: analytical and clinical performance.
• Robinson, CC. The value of RVP in children's hospitals.
• Petti, CA and Hillyard, D. Value of RVP in clinical settings: older adults.
• Mazzulli, T. Value of RVP in clinical settings: intensive care.

Public health surveillance

• Fox, JD. Respiratory virus surveillance and outbreak investigation.
• Lannigan, R and Mahony, JB. Issues for reporting results.
• Brice, GT et al. Respiratory virus panels for global surveillance of emerging infectious diseases.

Comparison of the Luminex xTAG respiratory viral panel with in-house nucleic acid amplification tests for diagnosis of respiratory virus infections.
Pabbaraju et al., JCM 2008 Sep;46(9):3056-62. Epub 2008 Jul 16.

• Key paper showing that xTAG RVP is of comparable sensitivity to in-house nucleic amplification tests, and may result in time and cost savings due to more efficient multiplexing. Free fulltext version
   

xTAG RVP and novel H1N1 influenza A (swine flu)

Likelihood that an unsubtypeable influenza A virus result obtained with the Luminex xTAG respiratory virus panel is indicative of infection with novel A/H1N1 (swine-like) influenza virus.
Ginocchio et al., JCM 2009 Jul;47(7):2347-8. Epub 2009 Jun 3.

• Paper showing that xTAG RVP has high specificity for the detection of non-seasonal H1 or H3 influenza A viruses, and that a test result of non-subtypeable influenza A carries a high likelihood of being indicative of novel H1N1 (swine flu). Free fulltext version

Evaluation of multiple test methods for the detection of the novel 2009 influenza A (H1N1) during the New York City outbreak.
Ginocchio et al., JCV 2009 Jul;45(3):191-5. Epub 2009 Jun 16.

• Study showing that xTAG RVP was more sensitive than all other methods tested (rapid antigen tests, DFA, R-Mix culture) for detection of all influenza strains, including novel H1N1. PubMed citation

Multiplex PCR tests sentinel the appearance of pandemic influenza viruses including H1N1 swine influenza.
Mahony et al., JCV 2009 Jul;45(3):200-2. Epub 2009 Jun 6.

• Paper showing the value of xTAG RVP as a sentinel test (in patients with influenza-like illness) that could provide an early warning system for the detection of future pandemic influenza threats. PubMed citation
   

Cost-benefit analyses

Cost Analysis of Multiplex PCR Testing for Diagnosing Respiratory Virus Infections.
Mahony et al., JCM 2009 Jul 1. [Epub ahead of print]

• Cost analysis of respiratory virus testing in pediatric patients, showing that xTAG RVP is the least costly, compared with DFA (alone, plus SVC or plus RVP), in most cases. PubMed citation